reviewPhilosophical Transactions of the Royal Society B Biological SciencesSep 11, 2017BRONZE OA

Epstein–Barr virus infection and nasopharyngeal carcinoma

SWSai Wah TsaoCMChi Man TsangKWKwok Wai Lo

Chinese University of Hong Kong · University of Hong Kong · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chinese population. A strong association between NPC risk and the HLA locus at chromosome 6p has been identified, indicating a link between the presentation of EBV antigens to host immune cells and NPC risk. EBV infection in NPC is clonal in origin, strongly suggesting that NPC develops from the clonal expansion of a single EBV-infected cell. In epithelial cells, the default program of EBV infection is lytic replication. However, latent infection is the…

Citation impact

584
total citations
FWCI
13.72
Percentile
100%
References
158
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Nasopharyngeal carcinoma
  • Lytic cycle
  • Epstein–Barr virus
  • Biology
  • Virus
  • Epstein–Barr virus infection
  • Virology
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding