Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next- generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating…

• AO
  Academy of Finland

  Awards: 137389, 141140, 1272870
• FD
  Fonds De La Recherche Scientifique - FNRS

  Awards: WELBIO-CR-2012S-02R, T.0138.14
• WE
  Walloon excellence in life sciences and biotechnology
• ER
  European Research Council

  Awards: 336452-ENIGMO, 250172, Microbes4U_713547