A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients
Broad Institute · Harvard University · +8 more institutions
Abstract
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract that is associated with changes in the gut microbiome. Here, we sought to identify strain-specific functional correlates with IBD outcomes.
We performed metagenomic sequencing of monthly stool samples from 20 IBD patients and 12 controls (266 total samples). These were taxonomically profiled with MetaPhlAn2 and functionally profiled using HUMAnN2. Differentially abundant species were identified using MaAsLin and strain-specific pangenome haplotypes were analyzed using PanPhlAn.
Citation impact
- FWCI
- 16.59
- Percentile
- 100%
- References
- 33
Authors
22- ABA. Brantley HallCorresponding
Broad Institute, Harvard University, Massachusetts General Hospital
- MYMoran Yassour
Broad Institute, Harvard University, Massachusetts General Hospital
- JSJenny Sauk
Harvard University, University of California, Los Angeles, Massachusetts General Hospital
- AGAshley Garner
Broad Institute, Harvard University, Massachusetts General Hospital
- XJXiaofang Jiang
Broad Institute, Massachusetts Institute of Technology
Topics & keywords
- Ruminococcus
- Inflammatory bowel disease
- Biology
- Microbiome
- Dysbiosis
- Metagenomics
- Microbiology
- Disease
Funding
- NSNational Science FoundationAward: 1453942
- CACrohn's and Colitis Foundation of America
- HHHelen Hay Whitney Foundation
- KFKlarman Family Foundation
- CACharles A. King Trust
- CACrohn's and Colitis Foundation
- NINational Institutes of HealthAwards: U54DE023798, P30DK43351
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAwards: R01DK92405, P30DK43351, U54DE023798