In search of definitions: Cancer‐associated fibroblasts and their markers
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Abstract
The tumor microenvironment has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, cancer-associated fibroblasts (CAFs), a type of perpetually activated fibroblasts, have been implicated to have a strong tumor-modulating effect and play a key role in areas such as drug resistance. Identification of CAFs has typically been carried based on the expression of various "CAF markers", such as fibroblast activation protein alpha (FAP) and alpha smooth muscle actin (αSMA), which separates them from the larger pool of fibroblasts present in the body. However, as outlined in this Review, the expression of various commonly used fibroblast markers is extremely…
Citation impact
735
total citations
- FWCI
- 27.36
- Percentile
- 100%
- References
- 115
Citations per year
Authors
5Topics & keywords
Topics
Keywords
- Cancer
- Biology
- Pathology
- Computational biology
- Cancer research
- Medicine
- Oncology
- Genetics
UN Sustainable Development Goals
- Good health and well-being
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