A human gut bacterial genome and culture collection for improved metagenomic analyses

Forster, Samuel C.; Kumar, Nitin; Anonye, Blessing O.; Almeida, Alexandre; Viciani, Elisa; Stares, Mark; Dunn, Matthew; Mkandawire, Tapoka T.; Zhu, Ana; Shao, Yan; Pike, Lindsay J.; Louie, Thomas; Browne, Hilary P.; Mitchell, Alex; Neville, Bridget A.; FINN, ROBERT; Lawley, Trevor D.

doi:10.1038/s41587-018-0009-7

articleNature BiotechnologyFeb 1, 2019HYBRID OA

A human gut bacterial genome and culture collection for improved metagenomic analyses

SCSamuel C. Forster NKNitin Kumar BOBlessing O. Anonye AAAlexandre Almeida EVElisa Viciani

Wellcome Sanger Institute · Hudson Institute of Medical Research · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Understanding gut microbiome functions requires cultivated bacteria for experimental validation and reference bacterial genome sequences to interpret metagenome datasets and guide functional analyses. We present the Human Gastrointestinal Bacteria Culture Collection (HBC), a comprehensive set of 737 whole-genome-sequenced bacterial isolates, representing 273 species (105 novel species) from 31 families found in the human gastrointestinal microbiota. The HBC increases the number of bacterial genomes derived from human gastrointestinal microbiota by 37%. The resulting global Human Gastrointestinal Bacteria Genome Collection (HGG) classifies 83% of genera by abundance across 13,490 shotgun-sequenced metagenomic…

Citation impact

627

total citations

FWCI: 35.82
Percentile: 100%
References: 57

Citations per year

Authors

17

Topics & keywords

Topics

Keywords

Metagenomics
Biology
Microbiome
Genome
Shotgun sequencing
Bacterial genome size
Human Microbiome Project
Computational biology

No related works found for this paper.