A new genomic blueprint of the human gut microbiota

Almeida, Alexandre; Mitchell, Alex; Boland, Miguel; Forster, Samuel C.; Gloor, Gregory B.; Tarkowska, Aleksandra; Lawley, Trevor D.; FINN, ROBERT

doi:10.1038/s41586-019-0965-1

articleNatureFeb 11, 2019HYBRID OA

A new genomic blueprint of the human gut microbiota

AAAlexandre Almeida AMAlex Mitchell MBMiguel Boland SCSamuel C. Forster GBGregory B. Gloor

European Bioinformatics Institute · Wellcome Sanger Institute · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The composition of the human gut microbiota is linked to health and disease, but knowledge of individual microbial species is needed to decipher their biological roles. Despite extensive culturing and sequencing efforts, the complete bacterial repertoire of the human gut microbiota remains undefined. Here we identify 1,952 uncultured candidate bacterial species by reconstructing 92,143 metagenome-assembled genomes from 11,850 human gut microbiomes. These uncultured genomes substantially expand the known species repertoire of the collective human gut microbiota, with a 281% increase in phylogenetic diversity. Although the newly identified species are less prevalent in well-studied populations compared to…

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Topics & keywords

Topics

Keywords

Biology
Metagenomics
Genome
Microbiome
Human microbiome
Gut flora
Evolutionary biology
Repertoire

UN Sustainable Development Goals

Life in Land

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