Defining the role of Parasutterella , a previously uncharacterized member of the core gut microbiota

The genus of Parasutterella has been defined as a core component of the human and mouse gut microbiota, and has been correlated with various health outcomes. However, like most core microbes in the gastrointestinal tract (GIT), very little is known about the biology of Parasutterella and its role in intestinal ecology. In this study, Parasutterella was isolated from the mouse GIT and characterized in vitro and in vivo. Mouse, rat, and human Parasutterella isolates were all asaccharolytic and producers of succinate. The murine isolate stably colonized the mouse GIT without shifting bacterial composition. Notable changes in microbial-derived metabolites were aromatic amino acid, bilirubin, purine, and bile acid…

• UO
  University of Victoria
• AI
  Alberta Innovates - Technology Futures
• UO
  University of Alberta
• GB
  Genome British Columbia
• CN
  Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

  Award: Discovery Grant # 436154
• AI
  Alberta Innovates