Extensive transmission of microbes along the gastrointestinal tract

The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. This establishes the oral cavity…

• FN
  Fonds National de la Recherche Luxembourg

  Award: CORE/15/BM/10404093
• HE
  H2020 European Research Council

  Award: ERC-AdG-669830
• HM
  H2020 Marie Skłodowska-Curie Actions

  Award: 661019