reviewFrontiers in OncologyAug 6, 2019GOLD OA

The Global Landscape of EBV-Associated Tumors

CSClaire Shannon‐LoweABAlan B. Rickinson

University of Birmingham

PubMed
Indexed incrossrefdoajpubmed

Abstract

Epstein-Barr virus (EBV), a gamma-1 herpesvirus, is carried as a life-long asymptomatic infection by the great majority of individuals in all human populations. Yet this seemingly innocent virus is aetiologically linked to two pre-malignant lymphoproliferative diseases (LPDs) and up to nine distinct human tumours; collectively these have a huge global impact, being responsible for some 200,000 new cases of cancer arising worldwide each year. EBV replicates in oral epithelium but persists as a latent infection within the B cell system and several of its diseases are indeed of B cell origin; these include B-LPD of the immunocompromised, Hodgkin Lymphoma (HL), Burkitt Lymphoma (BL), Diffuse Large B cell Lymphoma…

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Keywords
  • Medicine
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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