Monocarboxylate transporters in cancer

BACKGROUND: Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer cells may use 4 main fuels that are shuttled in 5 different metabolic pathways. Glucose fuels glycolysis that can be coupled to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in oxidative cancer cells or to lactic fermentation in proliferating and in hypoxic cancer cells. Lipids fuel lipolysis, glutamine fuels glutaminolysis, and lactate fuels the oxidative pathway of lactate, all of which are coupled to the TCA cycle and OXPHOS for energy production. This review focuses on the latter metabolic pathway. SCOPE OF…

• FL
  Fondation Louvain
• FD
  Fonds De La Recherche Scientifique - FNRS
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca
• ST
  Stichting Tegen Kanker

  Award: FAF-F/2018/1282
• H2
  Horizon 2020 Framework Programme
• H2
  Horizon 2020

  Awards: 722605, 642623