NAD  +  cleavage activity by animal and plant TIR domains in cell death pathways

Horsefield, S.; Burdett, Hayden; Zhang, Xiaoxiao; Manik, M.K.; Shi, Yun; Chen, Jian; Qi, Tiancong; Gilley, Jonathan; Lai, Jhih‐Siang; Rank, Maxwell X.; Casey, Lachlan W.; Gu, Weixi; Ericsson, Daniel J.; Foley, Gabriel; Hughes, Robert; Bosanac, Todd; Itzstein, Mark von; Rathjen, John P.; Nanson, Jeffrey D.; Bodén, Mikael; Dry, Ian B.; Williams, Simon J.; Staskawicz, Brian J.; Coleman, Michael P.; Ve, Thomas; Dodds, Peter N.; Kobe, Boštjan

doi:10.1126/science.aax1911

articleScienceAug 23, 2019GREEN OA

NAD + cleavage activity by animal and plant TIR domains in cell death pathways

SHS. Horsefield HBHayden Burdett XZXiaoxiao Zhang MMM.K. Manik YSYun Shi

The University of Queensland · Australian National University · +9 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield et al. and Wan et al. report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD + ) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD + depletion during Wallerian degeneration of neurons. Science , this issue p. 793 , p. 799

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Topics & keywords

Topics

Keywords

NAD+ kinase
Cofactor
Nicotinamide adenine dinucleotide
Biology
Receptor
Pathogen
Programmed cell death
Signal transduction

UN Sustainable Development Goals

Good health and well-being

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