Tumor angiogenesis: causes, consequences, challenges and opportunities

Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as progenitors or cancer stem cells. Anti-angiogenic therapies using either antibodies or tyrosine kinase inhibitors have been approved to treat several types of cancer. However, the benefit of treatment has so far been modest, some patients not responding at all and others acquiring resistance. It is becoming increasingly clear that blocking tumors from accessing the…

• C
  Cancerfonden

  Awards: CAN 2015/1216, CAN 2017/502
• V
  Vetenskapsrådet

  Award: 2016-02495
• B
  Barncancerfonden

  Awards: PR2018-0148, TJ2017-0004
• UU
  Uppsala Universitet
• EO
  Emil och Wera Cornells Stiftelse