reviewAnnual Review of PhysiologyNov 15, 2019BRONZE OA

The Acidic Tumor Microenvironment as a Driver of Cancer

EBEbbe BoedtkjerSFStine F. Pedersen

Aarhus University · University of Copenhagen

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Abstract

Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH influence cancer and stromal cell function, their mutual interplay, and their interactions with the extracellular matrix. Tumor pH is spatially and temporally heterogeneous, and the fitness advantage of cancer cells adapted to extracellular acidity is likely particularly evident when they encounter less acidic tumor regions, for instance, during invasion. Through complex effects on genetic stability, epigenetics, cellular metabolism, proliferation, and survival, the…

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1,214
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Topics & keywords

Topics
Keywords
  • Tumor microenvironment
  • Extracellular matrix
  • Extracellular
  • Cancer cell
  • Stromal cell
  • Epigenetics
  • Cancer
  • Cell biology
UN Sustainable Development Goals
  • Clean water and sanitation
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