AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications
Sichuan University · Jiangsu Cancer Hospital · +1 more institution
Abstract
Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling pathway is associated with tumour cell growth, metastasis, invasion, epithelial-mesenchymal transition (EMT), angiogenesis, drug resistance, immune regulation and stem cell maintenance. Different therapeutic agents targeting AXL have been developed, typically including small molecule inhibitors, monoclonal antibodies (mAbs), nucleotide aptamers, soluble receptors, and several natural compounds. In this review, we first provide a comprehensive discussion of the structure, function, regulation, and…
Citation impact
- FWCI
- 17.84
- Percentile
- 100%
- References
- 266
Authors
3Topics & keywords
- GAS6
- Biology
- Receptor tyrosine kinase
- AXL receptor tyrosine kinase
- Cancer research
- Metastasis
- Angiogenesis
- Receptor Protein-Tyrosine Kinases
- Good health and well-being