Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

BACKGROUNDAn increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in individuals with NAFLD. The physiological factors that stimulate hepatic DNL and the effect of weight loss on hepatic DNL are not clear.METHODSHepatic DNL, 24-hour integrated plasma insulin and glucose concentrations, and both liver and whole-body insulin sensitivity were determined in individuals who were lean (n = 14), obese with normal IHTG content (n = 26), or obese with NAFLD (n = 27). Hepatic DNL was assessed using the deuterated water method corrected for the potential confounding…

• AO
  Academy of Nutrition and Dietetics Foundation
• CO
  College of Natural Resources, University of California Berkeley
• PS
  Pershing Square Foundation
• AO
  Academy of Nutrition and Dietetics
• NI
  National Institutes of Health

  Awards: DK56341, RR024992, DK52574, DK56341,DK20579,DK52574,RR024992, DK20579