Clostridium species as probiotics: potentials and challenges

Abstract Clostridium species, as a predominant cluster of commensal bacteria in our gut, exert lots of salutary effects on our intestinal homeostasis. Up to now, Clostridium species have been reported to attenuate inflammation and allergic diseases effectively owing to their distinctive biological activities. Their cellular components and metabolites, like butyrate, secondary bile acids and indolepropionic acid, play a probiotic role primarily through energizing intestinal epithelial cells, strengthening intestinal barrier and interacting with immune system. In turn, our diets and physical state of body can shape unique pattern of Clostridium species in gut. In view of their salutary performances, Clostridium…

• NN
  National Natural Science Foundation of China

  Awards: 31722054, 31829004, and 31722054, B16044, 31930106, 31930106, 31829004 and 31722054
• HE
  Higher Education Discipline Innovation Project

  Award: B16044