The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Nejman, Deborah; Livyatan, Ilana; Fuks, Garold; Gavert, Nancy; Zwang, Yaara; Geller, Leore T.; Rotter-Maskowitz, Aviva; Weiser, Roi; Mallel, Giuseppe; Gigi, Elinor; Meltser, Arnon; Douglas, Gavin M.; Kamer, Iris; Gopalakrishnan, Vancheswaran; Dadosh, Tali; Levin‐Zaidman, Smadar; Avnet, Sofia; Atlan, Tehila; Cooper, Zachary A.; Arora, Reetakshi; Cogdill, Alexandria P.; Khan, Md Abdul Wadud; Ologun, Gabriel O; Bussi, Yuval; Weinberger, Adina; Lotan‐Pompan, Maya; Golani, Ofra; Perry, Gili; Rokah, Merav; Bahar‐Shany, Keren; Rozeman, Elisa A.; Blank, Christian U.; Ronai, Anat; Shaoul, Ron; Amit, Amnon; Dorfman, Tatiana; Kremer, Ran; Cohen, Zvi R.; Harnof, Sagi; Siegal, Tali; Yehuda‐Shnaidman, Einav; Gal‐Yam, Einav Nili; Shapira, Hagit; Baldini, Nicola; Langille, Morgan G. I.; Ben‐Nun, Alon; Kaufman, Bella; Nissan, Aviram; Golan, Talia; Dadiani, Maya; Levanon, Keren; Bar, Jair; Yust‐Katz, Shlomit; Barshack, Iris; Peeper, Daniel S.; Raz, Dan J.; Segal, Eran; Wargo, Jennifer A.; Sandbank, Judith; Shental, Noam; Straussman, Ravid

doi:10.1126/science.aay9189

articleScienceMay 28, 2020GREEN OA

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

DNDeborah Nejman ILIlana Livyatan GFGarold Fuks NGNancy Gavert YZYaara Zwang

Weizmann Institute of Science · Tel Aviv University · +17 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with…

Citation impact

2,353

total citations

FWCI: 94.60
Percentile: 100%
References: 78

Citations per year

Authors

61

Topics & keywords

Topics

Keywords

Bacteria
Microbiome
Intracellular
Intracellular parasite
Biology
Human microbiome
Computational biology
Microbiology

No related works found for this paper.