Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma
Tongji University · Shanghai Tenth People's Hospital · +5 more institutions
Abstract
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75-85% of primary liver cancers, and sorafenib is the first targeted drug for advanced HCC treatment. However, sorafenib resistance is common because of the resultant enhancement of aerobic glycolysis and other molecular mechanisms. Aerobic glycolysis was firstly found in HCC, acts as a hallmark of liver cancer and is responsible for the regulation of proliferation, immune evasion, invasion, metastasis, angiogenesis, and drug resistance in HCC. The three rate-limiting enzymes in the glycolytic pathway, including hexokinase 2 (HK2),…
Citation impact
- FWCI
- 30.27
- Percentile
- 100%
- References
- 220
Authors
8- JFJiao FengCorresponding
Tongji University, Shanghai Tenth People's Hospital, Central Hospital of Putuo District
- JLJingjing Li
Tongji University, Shanghai Tenth People's Hospital, Central Hospital of Putuo District
- LWLiwei Wu
Tongji University, Shanghai Tenth People's Hospital
- QYQiang Yu
Tongji University, Shanghai Tenth People's Hospital
- JJJie Ji
Tongji University, Shanghai Tenth People's Hospital
Topics & keywords
- Hepatocellular carcinoma
- Glycolysis
- Anaerobic glycolysis
- Cancer research
- Apoptosis
- Medicine
- Internal medicine
- Oncology
- Good health and well-being