Targeting STAT3 in Cancer Immunotherapy
Indexed incrossrefdoajpubmed
Abstract
As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune response. STAT3 is broadly hyperactivated both in cancer and non-cancerous cells within the tumor ecosystem and plays important roles in inhibiting the expression of crucial immune activation regulators and promoting the production of immunosuppressive factors. Therefore, targeting the STAT3 signaling pathway has emerged as a promising therapeutic strategy for numerous cancers. In this review, we outline the importance of STAT3 signaling pathway in tumorigenesis and its immune regulation, and highlight the current status for the…
Citation impact
1,034
total citations
- FWCI
- 37.41
- Percentile
- 100%
- References
- 189
Citations per year
Authors
6Topics & keywords
Topics
Keywords
- STAT3
- Biology
- Immunotherapy
- Cancer research
- Carcinogenesis
- STAT protein
- Immune system
- Cancer immunotherapy
No related works found for this paper.
Funding
- NNNational Natural Science Foundation of ChinaAwards: 2018ZX09201018, 81570527, 91540113, 81970561, 81502631
- SUSichuan UniversityAwards: ZYJC18049, 2018ZX09201018, Z20201003
- NMNational Major Science and Technology Projects of ChinaAward: 2018ZX09201018-005
- WCWest China Hospital, Sichuan UniversityAwards: ZYJC18049, 2018ZX09201018, Z20191005, 1.3.5, Z20201003