Dysregulated lipid metabolism links NAFLD to cardiovascular disease

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients. NAFLD and CVD share several common risk factors including obesity, insulin resistance, and type 2 diabetes (T2D). Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense low-density lipoprotein (LDL) particles, and decreased high-density lipoprotein cholesterol (HDL-C) levels, is often observed in NAFLD patients. SCOPE OF REVIEW: In this review, we highlight recent epidemiological studies evaluating the link between NAFLD and CVD risk. We further focus on recent mechanistic insights into…

• UD
  Université de Lille
• AN
  Agence Nationale de la Recherche

  Awards: ANR-16-RHUS-0006, ANR-10-LABX-46
• FP
  Fondation pour la Recherche Médicale
• AF
  Association Française pour l'Etude du Foie
• ER
  European Research Council

  Award: 694717