Selective autophagy of intracellular organelles: Recent research advances

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and invading pathogens via the lysosomal system (the vacuole in plants and yeast). Autophagy is generally induced by stress, such as oxygen-, energy-or amino acid-deprivation, irradiation, drugs, etc. In addition to non-selective bulk degradation, autophagy also occurs in a selective manner, recycling specific organelles, such as mitochondria, peroxisomes, ribosomes, endoplasmic reticulum (ER), lysosomes, nuclei, proteasomes and lipid droplets (LDs). This capability makes selective autophagy a major process in maintaining cellular homeostasis. The…

• UO
  University of Pittsburgh
• NN
  National Natural Science Foundation of China

  Awards: 81622050, U1801284, 81873209, 91754115, 31771531, 2017BT01Y036
• GP
  Guangdong Provincial Pearl River Talents Program

  Award: 2017BT01Y036
• SA
  Science and Technology Planning Project of Guangdong Province

  Awards: 2017B090901051, 2017BT01Y036, 2016A020215152