NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Sichuan University · State Key Laboratory of Biotherapy · +7 more institutions
Abstract
Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics. These effects are mainly achieved by the driving effect of NAD + on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple NAD + -dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA, RNA and proteins, or releasing second messenger cyclic ADP-ribose (cADPR) and NAADP + . Prolonged disequilibrium of…
Citation impact
- FWCI
- 53.53
- Percentile
- 100%
- References
- 687
Authors
9- NXNa Xie
Sichuan University, State Key Laboratory of Biotherapy
- LZLu Zhang
Sichuan University, State Key Laboratory of Biotherapy
- WGWei Gao
Sichuan University, State Key Laboratory of Biotherapy
- CHCanhua Huang
Sichuan University, State Key Laboratory of Biotherapy, Chengdu University of Traditional Chinese Medicine
- PHPeter Huber
German Cancer Research Center, Heidelberg University, University Hospital Heidelberg
Topics & keywords
- NAD+ kinase
- Nicotinamide adenine dinucleotide
- Biology
- Cofactor
- Enzyme
- Neurodegeneration
- Biochemistry
- DNA repair