COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

Yang, Mi; Wu, Xixi; Hu, Jinlong; Wang, Yingqiao; Wang, Yin; Zhang, Longshan; Huang, Weiqiang; Wang, Xiaoqing; Li, Nan; Liao, Liwei; Chen, Min; Xiao, Nanjie; Dai, Yongmei; Liang, Huazhen; Huang, Wenqi; Lü, Yuan; Pan, Hua; Li, Lu; Chen, Longhua; Liu, Laiyu; Li, Liang; Guan, Jian

doi:10.1016/j.jhep.2022.01.009

articleJournal of HepatologyJan 29, 2022HYBRID OA

COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

MYMi Yang XWXixi Wu JHJinlong Hu YWYingqiao Wang YWYin Wang

Nanfang Hospital · Southern Medical University · +8 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

•Decreased COMMD10 induces radioresistance through intracellular Cu accumulation in HCC.•COMMD10 inhibits HIF1α/CP positive feedback loop to enhance radiosensitivity by disrupting Cu-Fe balance.•Cu accumulation upregulates CP to reduce Fe concentration and inhibit lipid peroxidation and ferroptosis.•COMMD10, HIF1α, CP and SLC7A11 might be potential new targets and predictive biomarkers of radioresistant HCC. Background & AimsCopper (Cu) is an essential trace element whose serum levels have been reported to act as an effective indicator of the efficacy of radiotherapy. However, little is known about the role of Cu in radiotherapy. In this study we aimed to determine this role and investigate the precise…

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Topics & keywords

Topics

Keywords

Radioresistance
Radiosensitivity
Chemistry
In vivo
Radiosensitizer
Cancer research
Hepatocellular carcinoma
Clonogenic assay

UN Sustainable Development Goals

Good health and well-being

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