Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Huazhong Agricultural University
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Abstract
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial cell membrane and periplasm and remove diverse extraneous substrates, including antimicrobials, organic solvents, toxic heavy metals, etc., from bacterial cells. This review systematically and comprehensively summarizes the functions of multiple efflux pumps families and discusses their potential applications. The biological functions of efflux pumps including their promotion of multidrug resistance, biofilm formation, quorum sensing, and survival and…
Citation impact
251
total citations
- FWCI
- 14.52
- Percentile
- 100%
- References
- 161
Citations per year
Authors
9Topics & keywords
Topics
Keywords
- Efflux
- Periplasmic space
- Microbiology
- Multiple drug resistance
- Antimicrobial
- Bacteria
- Antibiotic resistance
- Quorum sensing
UN Sustainable Development Goals
- Clean water and sanitation
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