Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged mitochondria could cause serious consequences even lead to cell death. Therefore, maintaining the homeostasis of mitochondria is critical for cellular functions. Mitophagy is a process of selectively degrading damaged mitochondria under mitochondrial toxicity conditions, which plays an essential role in mitochondrial quality control. The abnormal mitophagy that aggravates mitochondrial dysfunction is closely related to the pathogenesis of many diseases. As the myocardium is a highly oxidative metabolic tissue, mitochondria play a…

• NN
  National Natural Science Foundation of China

  Awards: 2018YFA0107102, 81970333, 2017YFA0105601, 31901044
• NK
  National Key Research and Development Program of China

  Awards: 2017YFA0105601, 2018YFA0107102, 2018YFA0107102, 2017YFA0105601, 81970333, 31901044
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2017YFA0105601