Circulating levels of IGF-1 directly regulate bone growth and density
National Institute of Diabetes and Digestive and Kidney Diseases · Jackson Laboratory · +4 more institutions
Abstract
IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS). This complex prolongs the half-life of serum IGFs and facilitates their endocrine actions. Liver IGF-1–deficient (LID) mice and ALS knockout (ALSKO) mice exhibited relatively normal growth and development, despite having 75% and 65% reductions in serum IGF-1 levels, respectively. Double gene disrupted mice were generated by crossing LID+ALSKO mice. These mice exhibited further reductions in serum IGF-1 levels and a significant reduction in linear growth. The…
Citation impact
- FWCI
- 13.50
- Percentile
- 100%
- References
- 32
Authors
11Topics & keywords
- Endocrinology
- Internal medicine
- Bone growth
- Protein subunit
- Pathophysiology
- Growth factor
- Osteoporosis
- Cortical bone