reviewFrontiers in PhysiologyAug 25, 2022GOLD OA

The AMPK pathway in fatty liver disease

CFChunqiu FangJPJianheng PanNQNing QuYLYuting LeiJHJiajun Han

Changchun University of Chinese Medicine

PubMed
Indexed incrossrefdoajpubmed

Abstract

Lipid metabolism disorders are the primary causes for the occurrence and progression of various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) caused by a high-fat diet and ethanol. AMPK signaling pathway plays an important role in ameliorating lipid metabolism disorders. Progressive research has clarified that AMPK signal axes are involved in the prevention and reduction of liver injury. Upregulation of AMK can alleviate FLD in mice induced by alcohol or insulin resistance, type 2 diabetes, and obesity, and most natural AMPK agonists can regulate lipid metabolism, inflammation, and oxidative stress in hepatocytes, consequently regulating FLD in…

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334
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100%
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Authors

7

Topics & keywords

Topics
Keywords
  • AMPK
  • Fatty liver
  • Lipid metabolism
  • Alcoholic fatty liver
  • Beta oxidation
  • Insulin resistance
  • Fatty acid metabolism
  • Metabolic pathway
UN Sustainable Development Goals
  • Good health and well-being
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