Lactate metabolism in human health and disease

The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao's research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological…

• NN
  National Natural Science Foundation of China

  Awards: 81870331, 21-1-4-rkjk-12-nsh
• NS
  Natural Science Foundation of Shandong Province

  Award: ZR2020MH045
• QM
  Qingdao Municipal Science and Technology Bureau

  Award: 21-1-4-rkjk-12-nsh