Cell death and inflammation during obesity: “Know my methods, WAT(son)”
University of Cologne · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Abstract
Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF family mediate cell death and inflammation within the adipose tissue, eventually resulting in lipid spill-over, glucotoxicity and insulin resistance. These events ultimately lead to ectopic lipid deposition, glucose intolerance and other metabolic complications with life-threatening consequences. Here we review the literature on how inflammatory responses affect metabolic processes such as energy homeostasis and insulin signalling. This review mainly focuses on the role of cell death in the adipose tissue as a key player in metabolic inflammation.
Citation impact
- FWCI
- 37.93
- Percentile
- 100%
- References
- 113
Authors
3- XHXimena HildebrandtCorresponding
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
- MAMohamed A. Ibrahim
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
- NPNieves Peltzer
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Topics & keywords
- Inflammation
- Insulin resistance
- Adipose tissue
- Medicine
- Obesity
- Homeostasis
- Glucose homeostasis
- Programmed cell death
- Good health and well-being