Signaling pathways and therapeutic interventions in gastric cancer

Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death. Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival, the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages, which leads to unsatisfactory prognosis and high recurrence rates. With the recent advances in genome analysis, biomarkers have been identified that have clinical importance for GC diagnosis, treatment, and prognosis. Modern molecular classifications have uncovered the vital roles that signaling pathways, including EGFR/HER2, p53, PI3K, immune checkpoint pathways, and cell adhesion signaling…

• SJ
  St. John's University
• NN
  National Natural Science Foundation of China

  Awards: 2018YFA0902801, U20A20379, 2021B1212040006
• SY
  Sun Yat-sen University

  Awards: 2021B1212040006, ZSQYBRJH0001
• NK
  National Key Research and Development Program of China

  Award: 2018YFA0902801
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2021A1515010117, 2018YFA0902801