Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

Mokrá, Daniela; Jošková, Marta; Mokrý, Juraj

doi:10.3390/ijms24010340

reviewInternational Journal of Molecular SciencesDec 25, 2022GOLD OA

Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

DMDaniela Mokrá MJMarta Jošková JMJuraj Mokrý

Comenius University Bratislava

PubMed

Indexed incrossrefpubmed

Abstract

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, and tissue-protective properties which may be useful in the treatment of various diseases, particularly in cancer, and neurological, cardiovascular, respiratory, and metabolic disorders. This article reviews current information on the biological effects of EGCG in the above-mentioned disorders in relation to molecular pathways controlling inflammation, oxidative stress, and cell apoptosis.

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297

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FWCI: 33.72
Percentile: 100%
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Topics & keywords

Topics

Keywords

Epigallocatechin gallate
Oxidative stress
Inflammation
Apoptosis
Polyphenol
Antioxidant
Intracellular
Signal transduction

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