Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics
Kyungpook National University · Yonsei University · +2 more institutions
Abstract
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate). Most butyrate producers belong to the Clostridium cluster of the phylum Firmicutes, such as Faecalibacterium , Roseburia , Eubacterium , Anaerostipes , Coprococcus , Subdoligranulum , and Anaerobutyricum . They metabolize carbohydrates via the butyryl-CoA: acetate CoA-transferase pathway and butyrate kinase terminal enzymes to produce most of butyrate. Although, in minor fractions, amino acids can also be utilized to generate butyrate via glutamate and lysine pathways. Butyrogenic microbes play a vital role in various gut-associated metabolisms. Butyrate is used…
Citation impact
- FWCI
- 85.76
- Percentile
- 100%
- References
- 175
Authors
7Topics & keywords
- Butyrate
- Roseburia
- Gut flora
- Biology
- Biochemistry
- Eubacterium
- Microbiology
- Fermentation