Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age
University of Utah · Salt Lake Regional Medical Center · +2 more institutions
Abstract
Aging results in an elevated burden of senescent cells, senescence-associated secretory phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low-grade inflammation and a host of age-related diseases. Recent evidence suggests that the clearance of senescent cells alleviates chronic inflammation and its associated dysfunction and diseases. However, the effect of this intervention on metabolic function in old age remains poorly understood. Here, we demonstrate that dasatinib and quercetin (D&Q) have senolytic effects, reducing age-related increase in senescence-associated β-galactosidase, expression of p16 and p21 gene and P16 protein in perigonadal white adipose tissue (pgWAT; all p…
Citation impact
- FWCI
- 55.68
- Percentile
- 100%
- References
- 52
Authors
8- MTMd Torikul Islam
University of Utah
- ETEric Tuday
University of Utah, Salt Lake Regional Medical Center, Geriatric Research Education and Clinical Center
- SAShanena Allen
Salt Lake Regional Medical Center, Geriatric Research Education and Clinical Center
- JKJohn Kim
Salt Lake Regional Medical Center, Geriatric Research Education and Clinical Center
- DWDaniel W. Trott
The University of Texas at Arlington
Topics & keywords
- Adipose tissue
- Dasatinib
- Inflammation
- Biology
- Quercetin
- Pharmacology
- Bioinformatics
- Function (biology)
- Good health and well-being
Funding
- OOOffice of Research and Development
- BLBiomedical Laboratory Research and Development, VA Office of Research and DevelopmentAward: BX004492
- NINational Institute on AgingAwards: AG048366, K08AG070281, AG060395, AG050238
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAwards: T35 DK103596, DK112826, DK108833