Targeting PI3K/AKT signaling pathway in obesity
Bulgarian Academy of Sciences · Center of Plant Systems Biology and Biotechnology · +1 more institution
Abstract
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients and intensifies societal health care costs. The development of safe and innovative prevention strategies and therapeutic approaches is thus of great importance. The complex pathophysiology of obesity involves multiple signaling pathways that influence energy metabolism in different tissues. The phosphatidylinositol 3-kinases (PI3K)/protein kinase B (AKT) pathway is critical for the metabolic homeostasis and its function in insulin-sensitive tissues is described in the context of health, obesity and obesity-related complications. The PI3K family participates in the regulation of diverse physiological processes…
Citation impact
- FWCI
- 53.04
- Percentile
- 100%
- References
- 149
Authors
5- MSMartina S. Savova
Bulgarian Academy of Sciences, Center of Plant Systems Biology and Biotechnology
- LVLiliya V. Mihaylova
Center of Plant Systems Biology and Biotechnology, Bulgarian Academy of Sciences
- DTDaniel Tews
Universität Ulm
- MWMartin Wabitsch
Universität Ulm
- MIMilen I. GeorgievCorresponding
Bulgarian Academy of Sciences, Center of Plant Systems Biology and Biotechnology
Topics & keywords
- PI3K/AKT/mTOR pathway
- Protein kinase B
- Context (archaeology)
- Autophagy
- Biology
- Signal transduction
- Cell biology
- Biochemistry