Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis
Seoul National University · Kyungpook National University · +4 more institutions
Abstract
Mitochondrial components have been abundantly detected in bone matrix, implying that they are somehow transported extracellularly to regulate osteogenesis. Here, we demonstrate that mitochondria and mitochondrial-derived vesicles (MDVs) are secreted from mature osteoblasts to promote differentiation of osteoprogenitors. We show that osteogenic induction stimulates mitochondrial fragmentation, donut formation, and secretion of mitochondria through CD38/cADPR signaling. Enhancing mitochondrial fission and donut formation through Opa1 knockdown or Fis1 overexpression increases mitochondrial secretion and accelerates osteogenesis. We also show that mitochondrial fusion promoter M1, which induces Opa1 expression,…
Citation impact
- FWCI
- 25.21
- Percentile
- 100%
- References
- 35
Authors
10Topics & keywords
- Cell biology
- Mitochondrion
- Osteoblast
- Secretion
- Mitochondrial fission
- mitochondrial fusion
- Biology
- Extracellular matrix