Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

Abstract Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or in combination in a variety of cancers, while it has been found to cause serious cardiac side effects in clinical application. More and more researchers are trying to explore the molecular mechanisms of DOX-induced cardiomyopathy (DIC), in which oxidative stress and inflammation are considered to play a significant role. This review summarizes signaling pathways related to oxidative stress and inflammation in DIC and compounds that exert cardioprotective effects by acting on relevant signaling pathways, including the role of Nrf2/Keap1/ARE, Sirt1/p66Shc, Sirt1/PPAR/PGC-1α signaling pathways and NOS, NOX, Fe 2+…

• SM
  Southwest Medical University
• KL
  Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province

  Award: HYX19014
• AH
  Affiliated Hospital of Southwest Medical University

  Award: YZZ2020001