Intestinal mucus components and secretion mechanisms: what we do and do not know

Abstract Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs. The mucus layer has attracted the attention of the scientific community in recent years, and with the discovery of new mucosal components, it has become increasingly clear that the mucosal barrier is a complex system composed of many components. Moreover, certain components are jointly involved in regulating the structure and function of the mucus barrier. Therefore, a comprehensive and systematic understanding of the functional components of the mucus layer is clearly…

• NN
  National Natural Science Foundation of China

  Awards: 81673163, 82273621, 201802, 81872620
• NU
  Ningbo University
• ZK
  Zhejiang Key Laboratory of Pathophysiology

  Award: 201802
• KC
  K. C. Wong Magna Fund in Ningbo University
• NS
  Natural Science Foundation of Zhejiang Province

  Award: LY21H260001