Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Macau University of Science and Technology · Quality Research · +3 more institutions
Abstract
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes which start with simple steatosis and lipid accumulation in the hepatocytes - a typical histological lesions characteristic. It may progress to non-alcoholic steatohepatitis (NASH) that is characterized by hepatic inflammation and/or fibrosis and subsequent onset of NAFLD-related cirrhosis and hepatocellular carcinoma (HCC). Due to the central role of the liver in metabolism, NAFLD is regarded as a result of and contribution to the metabolic abnormalities seen in the metabolic syndrome. Peroxisome proliferator-activated receptors (PPARs) has three subtypes, which govern the expression of genes responsible for energy…
Citation impact
- FWCI
- 46.72
- Percentile
- 100%
- References
- 139
Authors
4- YQYuan-ye Qiu
Macau University of Science and Technology, Quality Research
- JZJing Zhang
Hodges University, Macau University of Science and Technology
- FZFanyi ZengCorresponding
Shanghai Children's Hospital, Macau University of Science and Technology, Shanghai Jiao Tong University, Quality Research
- YZYi Zhun ZhuCorresponding
Macau University of Science and Technology, Quality Research
Topics & keywords
- Pioglitazone
- Steatohepatitis
- Fatty liver
- Metabolic syndrome
- Nonalcoholic fatty liver disease
- Peroxisome proliferator-activated receptor
- Rosiglitazone
- Insulin resistance
- Good health and well-being