Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
National Clinical Research Center for Digestive Diseases · First Affiliated Hospital Zhejiang University · +3 more institutions
Abstract
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment. Various cytokines, interferons, growth factors, and other specific molecules activate JAK-STAT signaling to drive a series of physiological and pathological processes, including proliferation, metabolism, immune response, inflammation, and malignancy. Dysregulated JAK-STAT signaling and related genetic mutations are strongly associated with immune activation and cancer progression. Insights into the structures and functions of the JAK-STAT pathway have led to the development and…
Citation impact
- FWCI
- 128.53
- Percentile
- 100%
- References
- 584
Authors
9- XCXue ChenCorresponding
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- QYQinfan Yao
First Affiliated Hospital Zhejiang University
- XGXinyu Gu
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- QSQingmiao Shi
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- XYXin Yuan
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
Topics & keywords
- stat
- JAK-STAT signaling pathway
- Janus kinase
- STAT protein
- Cancer research
- Signal transduction
- Biology
- Immune system
- Good health and well-being