Gut microbiota Turicibacter strains differentially modify bile acids and host lipids
Johns Hopkins University · University of California, Los Angeles · +3 more institutions
Abstract
Bacteria from the Turicibacter genus are prominent members of the mammalian gut microbiota and correlate with alterations in dietary fat and body weight, but the specific connections between these symbionts and host physiology are poorly understood. To address this knowledge gap, we characterize a diverse set of mouse- and human-derived Turicibacter isolates, and find they group into clades that differ in their transformations of specific bile acids. We identify Turicibacter bile salt hydrolases that confer strain-specific differences in bile deconjugation. Using male and female gnotobiotic mice, we find colonization with individual Turicibacter strains leads to changes in host bile acid profiles, generally…
Citation impact
- FWCI
- 45.20
- Percentile
- 100%
- References
- 84
Authors
10- JBJonathan B. LynchCorresponding
Johns Hopkins University, University of California, Los Angeles, Johns Hopkins Medicine
- ELErika L. Gonzalez
University of California, Los Angeles
- KCKayli Choy
University of California, Los Angeles
- KFKym F. Faull
University of Southern California, University of California, Los Angeles, Neurobehavioral Systems
- TJTalia Jewell
Topics & keywords
- Gut flora
- Host (biology)
- Microbiology
- Biology
- Chemistry
- Biochemistry
- Genetics