Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

Abstract Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease, and is characterized by liver inflammation and fat accumulation. Dietary interventions, such as fibre, have been shown to alleviate this metabolic disorder in mice via the gut microbiota. Here, we investigated the mechanistic role of the gut microbiota in ameliorating NASH via dietary fibre in mice. Soluble fibre inulin was found to be more effective than insoluble fibre cellulose to suppress NASH progression in mice, as shown by reduced hepatic steatosis, necro-inflammation, ballooning and fibrosis. We employed stable isotope probing to trace the incorporation of 13 C-inulin into gut bacterial genomes and…

• IF
  Impact Fund
• CU
  Chinese University of Hong Kong

  Award: 4930775
• HA
  Health and Medical Research Fund

  Awards: 7181256, 9202626