TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Institut Pasteur of Shanghai · Shanghai University of Traditional Chinese Medicine · +3 more institutions
Abstract
Abstract Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology: TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPML (Mucolipin), TRPN (NO-mechano-potential, NOMP), TRPP (Polycystin), TRPV (Vanilloid). They are a class of ion channels found in numerous tissues and cell types and are permeable to a wide range of cations such as Ca 2+ , Mg 2+ , Na + , K + , and others. TRP channels are responsible for various sensory responses including heat, cold, pain, stress, vision and taste and can be activated by a number…
Citation impact
- FWCI
- 88.25
- Percentile
- 100%
- References
- 732
Authors
6- MZMiao ZhangCorresponding
Institut Pasteur of Shanghai, Shanghai University of Traditional Chinese Medicine
- YMYueming Ma
Shanghai University of Traditional Chinese Medicine
- XYXianglu Ye
Shanghai University of Traditional Chinese Medicine
- NZNing Zhang
Shanghai University of Traditional Chinese Medicine
- LPLei Pan
Chinese Academy of Sciences, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences
Topics & keywords
- Transient receptor potential channel
- TRPV
- Ion channel
- Ankyrin repeat
- TRPC
- Chemistry
- TRPC1
- Stretch-activated ion channel
- Good health and well-being