reviewCell Host & MicrobeJul 1, 2023HYBRID OA

Intestinal mucus and their glycans: A habitat for thriving microbiota

ASAna S. LuísGCGunnar C. Hansson

University of Gothenburg

PubMed
Indexed incrossrefpubmed

Abstract

The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. In the intestine, goblet cells are specialized in controlling glycosylation and making mucus. Some microbiota members are known to encode multiple proteins that are predicted to bind and/or cleave mucin glycans. The interactions between commensal microbiota and host mucins drive intestinal colonization, while at the same time, the microbiota can utilize the glycans on mucins and affect the colonic mucus properties. This review…

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245
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FWCI
35.54
Percentile
100%
References
132
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Authors

2

Topics & keywords

Topics
Keywords
  • Mucin
  • Mucus
  • Biology
  • Glycan
  • Microbiology
  • Glycoprotein
  • Mucin 2
  • Secretion
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