Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

Abstract The mitochondrial permeability transition (mPT) describes a Ca 2+ -dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It is mediated by a non-selective channel, the mitochondrial permeability transition pore (mPTP). Sustained mPTP opening causes mitochondrial swelling, which ruptures the outer mitochondrial membrane leading to subsequent apoptotic and necrotic cell death, and is implicated in a range of pathologies. However, transient mPTP opening at various sub-conductance states may contribute several physiological roles such as alterations in mitochondrial bioenergetics and rapid Ca 2+…

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  Japan Agency for Medical Research and Development

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  Fondation Leducq

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  Ministry of Education, Culture, Sports, Science and Technology

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  AIRIcerca

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  National Institutes of Health

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  National Institute on Aging

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  National Heart, Lung, and Blood Institute

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  National Institute of General Medical Sciences

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  National Institute of Neurological Disorders and Stroke

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  Center of Innovation Program

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