PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
University of Palermo · National University of Singapore · +21 more institutions
Abstract
The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions with several other signaling pathways, and dysregulation of signal transduction can predispose to cancer development. The PAM axis is the most frequently activated signaling pathway in human cancer and is often implicated in resistance to anticancer therapies. Dysfunction of components of this pathway such as hyperactivity of PI3K, loss of function of PTEN, and gain-of-function of AKT, are notorious drivers of…
Citation impact
- FWCI
- 267.14
- Percentile
- 100%
- References
- 457
Authors
27- AGAntonino GlavianoCorresponding
University of Palermo
- ASAaron Song Chuan Foo
National University of Singapore, National University Hospital
- HYHiu Yan Lam
National University of Singapore, National University Cancer Institute, Singapore, National Cancer Centre Singapore
- KCKenneth Chun-Yong Yap
National University of Singapore, National University Cancer Institute, Singapore, National Cancer Centre Singapore
- WJWilliam Jacot
Inserm, Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier
Topics & keywords
- PI3K/AKT/mTOR pathway
- Biology
- Signal transduction
- Protein kinase B
- Cancer research
- RPTOR
- Cancer
- Transduction (biophysics)
- Good health and well-being