Protective Factors and the Pathogenesis of Complications in Diabetes
Joslin Diabetes Center · Harvard University · +3 more institutions
Abstract
Chronic complications of diabetes are due to myriad disorders of numerous metabolic pathways that are responsible for most of the morbidity and mortality associated with the disease. Traditionally, diabetes complications are divided into those of microvascular and macrovascular origin. We suggest revising this antiquated classification into diabetes complications of vascular, parenchymal, and hybrid (both vascular and parenchymal) tissue origin, since the profile of diabetes complications ranges from those involving only vascular tissues to those involving mostly parenchymal organs. A major paradigm shift has occurred in recent years regarding the pathogenesis of diabetes complications, in which the focus has…
Citation impact
- FWCI
- 33.14
- Percentile
- 100%
- References
- 272
Authors
6- MGMarc Gregory Yu
Joslin Diabetes Center, Harvard University
- DGDaniel Gordin
Joslin Diabetes Center, University of Helsinki, Harvard University, Helsinki University Hospital, Minerva Foundation
- JFJialin Fu
Joslin Diabetes Center, Harvard University
- KPKyoungmin Park
Joslin Diabetes Center, Harvard University
- QLQian Li
Joslin Diabetes Center, Harvard University
Topics & keywords
- Diabetes mellitus
- Medicine
- Pathogenesis
- Intensive care medicine
- Bioinformatics
- Disease
- Vascular disease
- Review article
- Good health and well-being
Funding
- ADAmerican Diabetes AssociationAwards: 9-18-CVD1-005, ADA 9-18-CVD1-005
- AAstraZeneca
- HYHelsingin Yliopisto
- JDJoslin Diabetes CenterAward: P30DK036836
- WOWilhelm och Else Stockmanns Stiftelse
- FLFinska Läkaresällskapet
- MFMinerva Foundation
- EAEuropean Association for the Study of Diabetes
- DRDiabetes Research CenterAward: P30DK036836
- NHNational Heart, Lung, and Blood Institute
- NENational Eye Institute
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAward: P30DK036836