ADP-ribosylation from molecular mechanisms to therapeutic implications

ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent emergence of new technologies to study ADP-ribosylation has reshaped our understanding of the molecular mechanisms that govern the establishment, removal, and recognition of this modification, as well as its impact on cellular and organismal function. These advances have also revealed the intricate involvement of ADP-ribosylation in human physiology and pathology and the enormous potential that their manipulation holds for therapy. In this review, we present the state-of-the-art findings covering the work in structural biology,…

• WT
  Wellcome Trust

  Awards: 210634, 223107
• VP
  Vertex Pharmaceuticals
• OC
  Ovarian Cancer Research Alliance

  Award: 813369
• NI
  National Institute for Health and Care Research
• UO
  University of Exeter

  Awards: MR/V033417/1, MR/N006364/2
• UO
  University of Oxford

  Award: USCF 456
• LC
  Ligue Contre le Cancer
• CN
  Centre National de la Recherche Scientifique
• SL
  Studium Loire Valley-Institute for Advanced Studies
• DF
  Directorate for Biological Sciences
• MR
  Medical Research Council

  Awards: MR/N006364, MR/N006364/2, MR/N006364/2, MR/X007472/1, MR/V033417/1, MR/V033417/1
• BA
  Biotechnology and Biological Sciences Research Council

  Award: BB/R007195/1