Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
University of Helsinki · Institute for Molecular Medicine Finland · +4 more institutions
Abstract
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide…
Citation impact
- FWCI
- 81.57
- Percentile
- 100%
- References
- 86
Authors
10Topics & keywords
- Lipidome
- Lipidomics
- Biology
- Genome-wide association study
- Phenome
- Genetics
- Disease
- Genome