Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer
Sichuan University · State Key Laboratory of Biotherapy · +3 more institutions
Abstract
Cancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition. This metabolic alteration, known as the Warburg effect, serves as a significant indicator of malignant tumor transformation. The Warburg effect primarily impacts cancer occurrence by influencing the aerobic glycolysis pathway in cancer cells. Key enzymes involved in this process include glucose transporters (GLUTs), HKs, PFKs, LDHs, and PKM2. Moreover, the expression of transcriptional regulatory factors and proteins, such as FOXM1, p53, NF-κB, HIF1α, and c-Myc, can also influence…
Citation impact
- FWCI
- 47.77
- Percentile
- 100%
- References
- 626
Authors
7- MLMinru Liao
Sichuan University, State Key Laboratory of Biotherapy
- DYDahong Yao
Shenzhen Technology University
- LWLifeng Wu
Sichuan University, State Key Laboratory of Biotherapy
- CLChaodan Luo
University of Southern California
- ZWZhiwen Wang
Shenzhen University, Sichuan University, Shenzhen Technology University, State Key Laboratory of Biotherapy
Topics & keywords
- Warburg effect
- Anaerobic glycolysis
- Cancer
- Tumor microenvironment
- Cancer research
- Cancer cell
- Glycolysis
- PKM2
- Good health and well-being