Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Gyeongsang National University
Indexed incrossrefdoajpubmed
Abstract
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis, chemoresistance, and the mechanistic backgrounds of individuals whose cancers are prone to migration. The most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase (MAPK) pathway, encompassing the RAS-RAF-MAPK kinase (MEK)-extracellular signal-related kinase (ERK) pathway. RAF kinase is a primary mediator of the MAPK pathway, responsible for the sequential activation of downstream targets, such as MEK and the transcription factor ERK, which control numerous…
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755
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- 109.09
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- 100%
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Authors
3Topics & keywords
Topics
Keywords
- MAPK/ERK pathway
- Cancer research
- Carcinogenesis
- Kinase
- Autophagy
- Biology
- Protein kinase A
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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